Langerhans Cells in Bone marrow biopsy 2

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Langerhans Cells in Bone marrow biopsy 2

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Author: Dr.Bilal Kazi MD,DM; Dr.Anupam Chakrapani MD,DM; Dr.Sudhanya Biswas MD
Category: Macrophage/Histiocytic and dendritic cell Neoplasms and disorders (2015) > L group > Langerhans cell histiocytosis (LCH)
Published Date: 09/10/2025

Since the patient also had bicytopenia (Anemia and mild leucopenia) a Bone marrow aspirate and bone marrow biopsy was done. BMA was hemodiluted. But the bone marrow biopsy showed Langerhans cell in a inflammatory background comprising of plasma cells and eosinophils.

Since the patient had skin rash, multiple lytic bone lesions with sclerosed margins and bone marrow biopsy demonstrating langerhans cells, a diagnosis of Multi-system Langerhans cell histiocytosis was made.

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