Cold agglutinin disease 2

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Cold agglutinin disease 2

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Author: Sumitha Baskaran; Madhura Jogwar; Amit Taori; Sanjay Gohil; Metropolis healthcare limited; Abhay Bhave; Shrinath Kshirsagar; Gleneagles hospital Mumbai
Category: Red Cell: Hemolytic Anemia (HA) > Autoimmune Hemolytic Anemias > Cold-active antibodies > Cold agglutinin disease (CAD) > Secondary CAD
Published Date: 12/19/2025

Automated CBC histograms (WBC, RBC, and PLT) from 5 part analyzer showing cold agglutinin–related interference: 1. RBC histogram shows a markedly broadened and irregular curve with loss of the normal peak and an extended tail, reflecting interference from red cell agglutination.

2. WBC histogram demonstrates distortion of the lower-size region due to misclassified agglutinated RBCs.

3. Platelet histogram shows a left-shifted curve with reduced small-particle counts, also attributable to red cell clumping affecting particle discrimination.

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