B-cell Acute Lymphoblastic Leukemia

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B-cell Acute Lymphoblastic Leukemia

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Author: Dr. Madhura Jogwar; Dr. Sumitha Baskaran; Metropolis Healthcare Ltd; Dr. Abhay Bhave; Dr. Shrinath Kshirsagar; Gleneagles Hospital, Mumbai
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Precursor Lymphoid Neoplasms > B-lymphoblastic leukemia/lymphoma
Published Date: 04/16/2026

A 15-year-old male presented with marked leukocytosis (WBC: 118,000 cells/cu.mm) with 85% blasts and thrombocytopenia. Peripheral smear (Leishman stain, low and high-power view) shows circulating blasts with high nuclear–cytoplasmic ratio, fine chromatin, inconspicous nucleoli and scant cytoplasm. Background RBCs are predominantly microcytic and hypochromic with anisocytosis; platelets are reduced. Flow cytometry revealed blasts positive for CD10, CD19, cCD79a, and HLA-DR, with negativity for myeloid and T-cell markers, consistent with B-cell Acute Lymphoblastic Leukemia (B-ALL).

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