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H&E-stained trephine biopsy,

H&E-stained trephine biopsy,
#00066373
Author: Shayan Ashfaq
Category: Infectious Disease > Fungi > Histoplasmosis  
Published Date: 04/16/2026

bone marrow infiltration by numerous histiocytes (macrophages) that appear distended and packed with small intracellular yeast forms; these organisms are seen as tiny (2–4 µm), round to oval basophilic bodies with a surrounding clear halo (pseudocapsule), often clustered within the cytoplasm of macrophages, with occasional extracellular forms.

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