Acrocynosis with Hemolytic Anaemia

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Acrocynosis with Hemolytic Anaemia

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Author: Dr.Meena Verma; Dr.Nitin Gupta; Dr; Priyamvadha R; Dr.Naman Bansal; Dr.Navneet Mishra; Dr.Cheemela Bhutia; Dr.Vineet Kumar
Category: Red Cell: Hemolytic Anemia (HA) > Autoimmune Hemolytic Anemias > Cold-active antibodies
Published Date: 05/01/2026

75 year old male presented to us with severe anemia ,Hemoglobin was 5 gm/dl .He had history of lower limbb gangrene for which he was planned for surgery latter developed severe anemia so refrrred to Clinical Hematology .On examination peripheral acrocynosis was present.PBF showed RBC agglutination not resolved at 37C.Direct coombs test was 4+.Monospecific showed positivity for IgG,C3d.Cold antibody were positive.He was treated with Inj Rituximab weekly .

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L-Before Rituximab

R -After 2 doses of Rituximab

His symptoms resolved .

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