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P. vivax developing trophozoites exhibit an irregular, amoeboid cytoplasm that looks active, spreading across the cell with prominent pseudopodial extensions. As the trophozoite matures, fine, yellowish-brown to golden-brown malarial pigment (hemozoin) accumulates and spreads within the cytoplasm.P. vivax preferentially infects reticulocytes; consequently, the infected RBC is significantly larger and paler than the surrounding uninfected cells. The cytoplasm of the infected erythrocyte displays fine, evenly distributed pink/red stippling known as Schüffner’s dots.