The Parvovirus in Bone Marrow

The Parvovirus in Bone Marrow
Author: Julio A. Diaz-Perez
Category: Infectious Disease
Published Date: 08/20/2012

Shown below are histopathologic images of parvovirus infected bone marrow samples. These were taken from a 46 year old post bone marrow transplant patient with chronic lymphocytic leukemia. Erythroid hyperplasia was observed (Hematoxylin and eosin, Figure a [100x] and b [400x]) as were numerous giant cells with prominent glassy eosinophilic nuclear inclusions and clear central halos (lantern cells). The cytoplasm was observed as being finely granulated, particularly in the case of basophilic and polychromatic erythroblasts that tested positive to glycophorin immunostaining (Figure c [400x]). The cytoplasm also revealed adequate megakaryocyte and myeloid precursors, both of which tested positive to myeloperoxidase (Figure d [400x]). All cells tested negative to cytomegalovirus immunostaining (Figure e [400x]).