Splenic Gandy-Gamna bodies are a benign finding associated with a number of pathologic conditions including portal hypertension, sickle cell disease, hemolytic anemia, splenic vein thrombosis, etc. They are believed to be the result of small areas of extravasated red blood cells within the splenic parenchyma as a consequence of these disorders. Together this extravasated hemosiderin with fibrotic reaction and dystrophic calcification forms nodules. Histologically, as seen in the above photograph, these nodules are areas of dense fibrosis encircling chunky, possibly refractile, yellow-to-brown-to-black iron and calcium deposition.