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Microgranular acute promyelocytic leukemia with hyperleukocytosis and autoimmune hemolysis

Author: Prateek Bhatia, MD, FRPATH, MBBS, 08/24/2019
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with t(15;17)(q22;q12); PML-RARA (and variants)
Published Date: 09/16/2019

Fig 1: Giemsa Stain (40X)-Peripheral blood film showing high TLC with many hypo-granular leukemic promyelocytes with characteristic bilobed nucleus

Fig 2: Giemsa Stain (100X)-Peripheral blood film showing leukemic hypo-granular promyelocytes; Red Arrow- Aeur rods; Black Arrows:- Schistocytes

Fig 3: Giemsa Stain (10X)-Peripheral blood film showing hyperleucocytosis along with prominent RBC clumping (black arrows)

Fig 4: Giemsa Stain (20X)-Peripheral blood film showing extensive RBC agglutination and leukemic promyelocytes