Secondary myelofibrosis

Author: Dr. Pradeep Arumugam, MD,DNB, 10/06/2021
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Myeloproliferative Neoplasms (MPN) > Polycythemia Vera (PV) > Post-polycythemic myelofibrosis
Published Date: 10/22/2021

71 year old male diagnosed  as polycyathemia rubra vera with JAK2 EXON 12 mutation  with low erythropoietin levels of 3.2 (4.3-29).patient was on treatment with hydroxyurea .

Bone marrow aspirate and  biopsy was done in view of lowering hemoglobin levels in our hospital . Bone marrow aspirate was a dry tap and was was aparticulate and hemodiluted .

Bone marrow biopsy findings showing post polycyathemic myelofibrosis  is given in these 4  images along with reticulin special stain