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Bone marrow -granulomatous inflammation with tuberculous etiology
Author: Dr. Pradeep Arumugam, MD,DNB, 10/07/2021
Category: Reactive Marrow > Reactive changes > Histiocytes > Granulomas
Published Date: 10/19/2021
- Bone marrow infiltration by granulomatous inflammation with tubercular etiology
- 51 year old male presented with complaints of fever since 2 months with multiple spleniclesions with retroperitoneal lymphnodes.
- Culture and sputum was negative was newly diagnosed as retro positive .
- PET CT showed multiple hypermetabolic marrow lesions seen involving the axial skeleton.
- Multiple hypermetabolic left cervical bilateral left cervical and bilateral subpectoral and mediastinal nodes were also noted.
- On clinical suspicion of lymphoma bone marrow aspirate and biopsy was perfomed and reported as marrow plasmacytosis of 15% on bone marrow aspirate.
- Bone marrow was sent to us.
- Biopsy showed partly preserved marrow spaces with 2- 3 intertrabecular spaces infiltrated by dense sheets of plasma cells along with prominent epitheliod cell granulmas admixed with histiocytes and lymphocytes.
- Ziehl Neelson stain was performed and yielded many slender long acid fast bacilli consistent with tuberculous etiology.
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