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Gaucher's Disease

Author: Vickie Lee; Ean Ooi, 01/01/2026
Category: Laboratory Hematology > Basic cell morphology > Morphologic variants of white blood cells > Histiocyte/macrophage – storage disease > Gaucher
Published Date: 02/04/2026
     
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Bone marrow aspirate and trephine of child with Gaucher's disease at diagnosis. A classic "wrinkled tissue paper" pattern is seen in the cytoplasm of the Gaucher cells on aspirate. They are highlighted by CD68, Periodic Acid-Schiff (PAS) and Tartrate-Resistant Acid Phosphatase (TRAP) stains on trephine.

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