Blasts in AML mutated NPM1
There is a marked leukocytosis with blasts comprising the majority of circulating peripheral blood leukocytes. The blasts are medium to large in size and have an elevated nuclear:cytoplasmic ratio. The nuclear chromatin is fine and there are prominent nucleoli. Frequent blasts show indented or “cup-shaped” nuclear contours.
Blasts comprised the majority (approximately 95%) of circulating peripheral blood and marrow leukocytes. An NPM1 exon 12 frameshift mutation was detected by PCR.