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Numerous target cells and scattered hemoglobin C crystals in a patient with hemoglobin C disease. Hemoglobin C crystals are dense rectangular structures composed of precipitated hemoglobin C. Target cells form when there is an excess of membrane in relation to cytosol. Microcytic target cells can be seen in thalassemia and other hemoglobinopathies. Macrocytic target cells can be seen in liver disease. Target cells can also be seen in hyposplenic patients, or as an artifact of slide preparation.