Therapy-related Myeloid Neoplasm- Bone marrow Aspirate 2

Main Navigation
Account Navigation
Main Content

JavaScript is disabled on your browser

Please enable JavaScript or upgrade to a JavaScript-capable browser to use the ASH Image Bank.

COLLECTION

Images of peripheral blood and/or bone marrow of blood disorders and normal hematopoiesis.
ATLAS

Normal and abnormal blood cells
REFERENCE CASES

Complete cases of common blood disorders (peripheral blood, bone marrow, and diagnostic studies).
UPLOAD IMAGES

Therapy-related Myeloid Neoplasm- Bone marrow Aspirate 2

#00063057

Author: Manisha Goel; Girish Venkataraman
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Therapy-related myeloid neoplasms
Published Date: 07/01/2020

Prominent megakaryocytic dysplasia is frequently observed in such cases. Note the multi-nucleated and non-lobated megakaryocytes with widely separated round nuclei (black arrow). One of the most reliable features of megakaryocytic dysplasia is the presence of a micromegakaryocyte (red arrow), which is approximately the size of a promyelocyte. Aberrant CD34 expression is often noted in dysplastic megakaryocytes and should be differentiated from blasts.

Scattered dysplastic neutrophils in the smears are notable for cytoplasmic hypo-granularity, abnormal nuclear segmentation and increased chromatin clumping (purple arrow) when compared to normal neutrophils (green arrow).

Download Image