Hemoglobin H disease (HbH) 2

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Hemoglobin H disease (HbH) 2

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Author: Najmaldin Saki Ph.D; Bita Bandar M.Sc; Mohammad Amin Vahid M.Sc; Inas Afzali Nezhad B.Sc
Category: Laboratory Hematology > Basics of automated cell counts > Causes of inaccurate platelet counts > Falsely high platelet counts > Hemoglobin H disease
Published Date: 05/28/2025

This image shows the peripheral blood smear of a 16 year-old female patient diagnosed with hemoglobin H disease (HbH). HbH disease is a form of alpha thalassemia(--/-α) in which moderately to severe anemia develops due to the reduced formation of alpha globin chains. (Hb=7.4 g/dL)
The smear is stained by Supravital (new methylene blue) to detect "golf-ball" HbH inclusions which are characteristic of HbH disease. About 6-8% golf-balls can be seen in this smear.

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