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ALCL cells in the bone marrow

ALCL cells in the bone marrow
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Author: Gurpreet Kaur, MD,DM; Ankur Ahuja; Shipra Verma; Michael John Kaniamparampil
Category: Lymphoma: Mature T and NK cell lymphoproliferations > Cutaneous T-cell Lymphoma > Primary Cutaneous CD30-positive T-cell Lymphoproliferative disorders > Anaplastic Large Cell Lymphoma
Published Date: 05/20/2026

Anaplastic Large Cell Lymphoma (ALCL) involving the marrow, presenting as large, pleomorphic, "anaplastic" cells with abundant cytoplasm and hallmark horseshoe-shaped nuclei. These cells often grow in a cohesive, clustered pattern, infiltrating as nodular or interstitial aggregates. They are consistently CD30-positive and may show ALK positivity. These must be distinguished from metastatic carcinomas, melanoma, or Hodgkin lymphoma. 

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