In this case, we present a 45 years old female patient suffering from thalassemia and sickle cell anemia. As you can see in figure 1 we presented complete blood count and hemoglobin (Hb) electrophoresis results. Patient showed microcytic – hypochromic anemia (RBC: 5.06/ μl; Hb: 11.6 g/dL; HCT: 36.8%; MCV: 72.7; MCH: 22.9; MCHC: 31.5; RDW: 18.8%) (Fig.1B) and Hb electrophoresis confirmed α thalassemia and sickle cell trait with following fractions: HbA (69.2%); HbF (1.9%); HbS (26.3%); HbA2 (2.2%); Z1 zone (0.4%) (Fig.1A). Also, you can see result of sickle cell prep test (shines from microscopic examination)