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APML with auer rods; Flow cytometry

Author: Charlotte Pattison, MSc, 10/22/2024
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with t(15;17)(q22;q12); PML-RARA (and variants)
Published Date: 10/31/2024
     
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57yo female presented in A/E with pancytopenia of unknown cause, thought to be due to bone marrow failure - so bone marrow aspirate was taken and investigated on. 

APML seen in images - promyelocytes with many Auer rods in the cytoplasm. 

These promyelocytes characterised by flow as CD117+ CD24- HLADR- CD33+ CD9+ CD13+ CD15+ cMPO+