GZL CD-45

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GZL CD-45

#00063804

Author: Arun Ravi; Girish Venkataraman, MD, MBBS
Category: Lymphoma: Mature B-cell and Plasma cell Neoplasms > Large B-cell lymphomas (not Richter transformation) > B-cell lymphoma unclassifiable with features intermediate between DLBCL and cHL
Published Date: 10/19/2021

CD45 is a transmembrane protein tyrosine phosphatase located on most hematopoietic cells. The CD45 antigen is normally universally expressed in variable intensities on all leukocytes. Classical Hodgkin lymphoma is almost always negative for CD45, but in this case, there is diffuse positivity in the neoplastic cells supporting gray zone designation.

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